Key result
Continuous infusion of ketamine did not significantly differ from normal saline in affecting hemodynamic responses, serum cortisol, or glucose concentrations during abdominal hysterectomy.
Why the study?
Does continuous intravenous ketamine infusion reduce the cortisol and hyperglycemic response in adult female patients undergoing abdominal hysterectomy under enflurane anesthesia?
RCT (n=20)
Does continuous intravenous ketamine infusion reduce the cortisol and hyperglycemic response in adult female patients undergoing abdominal hysterectomy under enflurane anesthesia?
Continuous infusion of ketamine does not significantly attenuate the cortisol and hyperglycemic stress responses to abdominal hysterectomy under enflurane anesthesia.
Ketamine infusion offers no benefit for stress attenuation in hysterectomy; confirms null effect on cortisol and glucose under enflurane.
Background: The effect of a continuous infusion of ketamine on the cortisol and hyperglycemic response induced by surgery was studied in patients undergoing an abdominal hysterectomy under enflurane anesthesia. Methods: Twenty adult female patients were randomly allocated to two groups receiving intravenous ketamine (0.3 mg/kg initially, followed by a continuous infusion at a rate of 0.15 mg/kg/h) (ketamine group, n = 10) or normal saline (control group, n = 10) 2 min after intubation. Hemodynamic responses, serum cortisol and glucose concentrations were measured before induction, 2 min after intubation, 2 min after incision, at closure of peritoneum and 5 min after extubation. Inspired and expired concentrations of enflurane were also evaluated. Results: There were no significant differences in hemodynamic responses, inspired and expired concentrations of enflurane, serum cortisol and glucose concentrations between the two groups. As compared with the values before induction, significant increases were seen in serum cortisol (control: 2.3-2.6 times, ketamine: 2-2.2 times) and glucose concentrations (control: 1.2-1.3 times, ketamine: 1.3 times) at closure of peritoneum and 5 min after extubation in both groups (P
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Baik et al. (2002) conducted an RCT in Abdominal hysterectomy under enflurane anesthesia (n=20). Ketamine vs. Normal saline was evaluated on Hemodynamic responses, serum cortisol and glucose concentrations. Continuous infusion of ketamine did not significantly differ from normal saline in affecting hemodynamic responses, serum cortisol, or glucose concentrations during abdominal hysterectomy.
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