What question did this study set out to answer?

To assess the progress of autonomic neuropathy in diabetes patients after six years.

March 1, 1985Diabetes Care

Autonomic Neuropathy in Diabetes Mellitus: A Follow-up Study

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Why the study?

Do baseline abnormalities in heart rate variability predict the development of symptomatic autonomic neuropathy in patients with diabetes?

Population

41 patients with diabetes mellitus without symptoms of autonomic neuropathy at baseline

Design

Cohort

Follow-up

6 years

Authors

GSG. SundkvistMalmö University BLB. LiljaNorra Älvsborgs Länssjukhus

Discussion

Member takes

Implication

HRV declines may precede symptomatic neuropathy in diabetes; hypothesis-generating, requires prospective validation before monitoring adoption.

Key Points

To assess the progress of autonomic neuropathy in diabetes patients after six years.
Re-investigated 41 patients with moderate and long-duration diabetes after 6 years.
Evaluated autonomic nerve function with heart reaction tests: deep breathing (E/I ratio) and rapid tilt (acceleration and brake indices).
Classified patients into two groups based on diabetes duration for comparison.
Symptoms of autonomic neuropathy developed in 18 patients (9 from each group).
Patients with symptoms (SAN) had low mean E/I ratio and brake index.
In group A, most SAN patients (8/9) had an abnormal acceleration index at follow-up.

Structured PICO

Do baseline abnormalities in heart rate variability predict the development of symptomatic autonomic neuropathy in patients with diabetes?

Population

41 patients with diabetes mellitus without symptoms of autonomic neuropathy at baseline (23 with moderate duration, 18 with long duration)

Outcome

Development of symptoms of autonomic neuropathy and changes in autonomic nerve function (E/I ratio, acceleration and brake indices)surrogate

Decreases in heart rate variability indices (E/I ratio and brake index) precede the rapid development of symptomatic autonomic neuropathy in diabetic patients.

Cite This Study

Sundkvist et al. (1985) studied this question.

synapsesocial.com/papers/6a219b7f153b2036cbf1e4cc https://doi.org/10.2337/diacare.8.2.129

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Implication

HRV declines may precede symptomatic neuropathy in diabetes; hypothesis-generating, requires prospective validation before monitoring adoption.

Autonomic Neuropathy in Diabetes Mellitus: A Follow-up Study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Autonomic Neuropathy in Diabetes Mellitus: A Follow-up Study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider