SummaryBlood was cross circulated from saline loaded donor dogs given excess min-eralocorticoid to normal recipient animals. A significant increase in urinary sodium excretion occurred in the recipients and this persisted despite a reduction in GFR produced by suprarenal aortic constriction. This decrease in fractional renal tubular sodium reabsorption is consistent with the action of a humoral factor.
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Johnston et al. (1966) studied this question.