Key result
High serum adiponectin levels combined with low BMI increased the risk of worsening depressive symptoms compared to low adiponectin and high BMI (OR 3.35; 95% CI 1.60-7.00; P=0.001).
Why the study?
Data regarding the association between adiponectin levels and BMI with long-term changes in depressive symptoms were limited and inconsistent.
Are high serum adiponectin levels and low BMI associated with worsening depressive symptoms in elderly individuals?
Cohort (n=269)
Are high serum adiponectin levels and low BMI associated with worsening depressive symptoms in elderly individuals?
In elderly Japanese individuals, the combination of high serum adiponectin levels and low BMI is significantly associated with a higher risk of worsening depressive symptoms over 10 years.
Answers are grounded in this paper and cite their sources.
High adiponectin with low BMI was associated with worsening depression in elderly; leaves open need for validation before any risk stratification.
Objectives: Data regarding the association between adiponectin levels and body mass index (BMI) and long-term changes in depressive symptoms are limited and inconsistent. Thus, we investigated whether circulating adiponectin levels and BMI were independently and combinedly correlated to longitudinal changes in depressive symptoms.Methods: This prospective cohort study evaluated 269 elderly Japanese individuals aged ≥70 years who participated in the Tsurugaya Project conducted between 2002 and 2012. A short form of the Geriatric Depression Scale (GDS) was used to assess depressive status. Serum adiponectin levels were measured using an enzyme-linked immunosorbent assay or a latex particle-enhanced turbidimetric immunoassay. BMI was calculated as body weight (kg)/height (m2).Results: Multiple linear regression analysis revealed that baseline serum adiponectin levels were positively associated with changes in GDS scores (β = 0.14, P = 0.035). However, no association was observed after adjusting for BMI (β = 0.09, P = 0.185). Low BMI was associated with increased GDS scores at the 10-year follow-up (β = -0.14, P = 0.033). Participants with a combination of high adiponectin levels and low BMI had a 3.3-fold higher risk of worsening depressive symptoms than those with low adiponectin levels and high BMI (odds ratio: 3.35, 95% confidence interval: 1.60–7.00; P = 0.001).Conclusions: This longitudinal study indicated that high serum adiponectin levels and low BMI were both associated with worsening depressive symptoms among older Japanese individuals. Furthermore, the combination of high adiponectin levels and low BMI was associated with worsening depressive symptoms.
No takes yet. Share an insight, caveat, or question.
Huang et al. (2019) conducted a cohort in depressive symptoms (n=269). High adiponectin levels and low BMI vs. Low adiponectin levels and high BMI was evaluated on worsening depressive symptoms (OR 3.35, 95% CI 1.60-7.00, p=0.001). High serum adiponectin levels combined with low BMI increased the risk of worsening depressive symptoms compared to low adiponectin and high BMI (OR 3.35; 95% CI 1.60-7.00; P=0.001).
Synapse has enriched 10 related papers. Consider them for comparative context: