Key result
Peripheral artery disease was associated with significantly decreased cognitive performance and impaired neurovascular coupling and microvascular endothelial function.
Observational
Cognitive decline in older adults with peripheral artery disease may be mechanistically linked to generalized microvascular endothelial dysfunction and impaired neurovascular coupling.
PAD-linked cognitive decline may involve microvascular dysfunction; hypothesis-generating, needs prospective validation before practice implications.
Peripheral artery disease (PAD) was associated with significantly decreased cognitive performance, impaired neurovascular coupling (NVC) responses in the prefrontal cortex (PFC), left and right dorsolateral prefrontal cortices (LDLPFC and RDLPFC), and impaired peripheral microvascular endothelial function. A positive correlation between microvascular endothelial function, NVC responses, and cognitive performance may suggest that PAD-related cognitive decrement is mechanistically linked, at least in part, to generalized microvascular endothelial dysfunction and subsequent impairment of NVC responses.
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Owens et al. (2022) conducted an observational in Peripheral artery disease (PAD). Peripheral artery disease was evaluated on Cognitive performance, neurovascular coupling responses, and peripheral microvascular endothelial function. Peripheral artery disease was associated with significantly decreased cognitive performance and impaired neurovascular coupling and microvascular endothelial function.
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