A Biocurator Perspective: Annotation at the Research Collaboratory for Structural Bioinformatics Protein Data Bank

ike most scientists, annotators at the Research Collaboratory for Structural Bioinformatics (RCSB) (http://www.pdb.org) dread the immortal cocktail party question ''So, what do you do?'' Unlike for some jobs, however, their answer can leave other scientists at the party with no response. Even within the structural biology community, our job is not well-understood. Throughout this perspective, we will shed light on the daily challenges faced by annotators at the RCSB and give the reader a glimpse at the juggling act that defines the job of a biocurator.