Key result
Baseline ECG LVH linked to ~69% greater risk of future renal function decline.
Why the study?
Electrocardiographic LVH predicts adverse renal outcomes in hypertension, but its association with future renal function decline in the general population required investigation.
Does baseline electrocardiographic left ventricular hypertrophy predict future renal function decline in the general population?
Cohort (n=19,825)
No
Does baseline electrocardiographic left ventricular hypertrophy predict future renal function decline in the general population?
Hazard Ratio: 1.69 (95% CI 1.14–2.5)
Absolute Event Rate: 0.78% vs 0.3%
p-value: p=0.009
Baseline electrocardiographic left ventricular hypertrophy is an independent predictor of future renal function decline in the general population, highlighting its utility for early risk stratification.
May aid renal risk identification; leaves open whether ECG LVH improves prediction beyond standard factors.
Electrocardiographic left ventricular hypertrophy (LVH) could predict adverse renal outcomes in patients with hypertension. This study aimed to investigate the association between electrocardiographic LVH and future decline in renal function in the general population using a dataset of population-based health checkups from 2010 to 2019 including 19,825 participants. Electrocardiographic LVH was defined according to the Minnesota code. Renal function decline was defined as a decrease of ≥ 25% in the estimated glomerular filtration rate from baseline to < 60 mL/min/1.73 m 2 . Electrocardiographic LVH was found in 1263 participants at the baseline visit. The mean follow-up period was 3.4 ± 1.9 years. The incidence rates of renal function decline were 0.30 and 0.78 per 100 person-years in the non-LVH group and LVH groups, respectively. Electrocardiographic LVH was associated with the risk for renal function decline in the adjusted analysis (hazard ratio 1.69, 95% confidence interval 1.14–2.50, P = 0.009). This association was comparable across subgroups stratified by age, sex, body mass index, diagnosed hypertension, systolic blood pressure, hemoglobin A1c, and urinary protein. This study underscores the usefulness of electrocardiographic LVH to detect high-risk individuals for renal function decline in the setting of health checkups in the general population.
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Ikeda et al. (2024) conducted a cohort in General population (n=19,825). Electrocardiographic left ventricular hypertrophy (LVH) vs. Absence of electrocardiographic LVH was evaluated on Renal function decline (decrease of ≥ 25% in eGFR from baseline to < 60 mL/min/1.73 m2) (HR 1.69, 95% CI 1.14-2.50, p=0.009). Baseline electrocardiographic left ventricular hypertrophy was associated with a 69% increased risk of future renal function decline (HR 1.69) compared to individuals without LVH in the general population.
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