Key result
In survived neonatal piglets, myocardial contractile function remained stable 6 hours after cardiopulmonary bypass and mild hypothermia, with no statistically significant differences compared to non-CPB controls.
Why the study?
Does cardiopulmonary bypass with mild hypothermia reduce myocardial contractility in neonatal piglets?
Does cardiopulmonary bypass with mild hypothermia reduce myocardial contractility in neonatal piglets?
Myocardial contractile function in neonatal piglets remained stable 6 hours after cardiopulmonary bypass and mild hypothermia, suggesting ischemic contracture and metabolic response could be avoided in this setting.
Answers are grounded in this paper and cite their sources.
Stable contractility after CPB in neonatal piglets does not change practice; leaves open translation to human infants.
BACKGROUND: Hemodynamic function may be depressed in the early postoperative stages after cardiac surgery. The aim of this study was the analysis of the myocardial contractility in neonates after cardiopulmonary bypass (CPB) and mild hypothermia. METHODS: Three indices of left ventricular myocardial contractile function (dP/dt, (dP/dt)/P, and wall thickening) were studied up to 6 hours after CPB in neonatal piglets (CPB group; n = 4). The contractility data were analysed and then compared to the data of newborn piglets who also underwent median thoracotomy and instrumentation for the same time intervals but without CPB (non-CPB group; n = 3). RESULTS: Left ventricular dP/dtmax and (dP/dtmax)/P remained stable in CPB group, while dP/dtmax decreased in non-CPB group 5 hours postoperatively (1761 ± 205 mmHg/s at baseline vs. 1170 ± 205 mmHg/s after 5 h; p < 0.05). However, with regard to dP/dtmax and (dP/dtmax)/P there were no statistically significant differences between the two groups. Comparably, although myocardial thickening decreased in the non-CPB group the differences between the two groups were not statistically significant. CONCLUSIONS: The myocardial contractile function in survived neonatal piglets remained stable 6 hours after cardiopulmonary bypass and mild hypothermia probably due to regional hypercontractility.
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Tirilomis et al. (2010) studied Myocardial contractile function post-surgery (n=7). Cardiopulmonary bypass (CPB) and mild hypothermia vs. Median thoracotomy and instrumentation without CPB was evaluated on Left ventricular dP/dt max at 5 hours postoperatively (p=not significant). In survived neonatal piglets, myocardial contractile function remained stable 6 hours after cardiopulmonary bypass and mild hypothermia, with no statistically significant differences compared to non-CPB controls.
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