Key result
Patients with Hashimoto's thyroiditis had significantly higher serum RDW levels compared to controls (10.08% vs 8.95%, p=0.003), indicating potential subclinical inflammation.
Why the study?
The authors aimed to use RDW to detect increased cardiovascular events, increased oxidative stress, and inflammation in patients with Hashimoto thyroiditis without additional cost.
Are RDW levels increased in patients with Hashimoto's thyroiditis compared to healthy controls?
Case-Control (n=904)
No
Are RDW levels increased in patients with Hashimoto's thyroiditis compared to healthy controls?
RDW is significantly elevated in patients with Hashimoto's thyroiditis and correlates with hs-CRP, suggesting its potential utility as a marker for subclinical inflammation and cardiovascular risk in this population.
Answers are grounded in this paper and cite their sources.
Elevated RDW may mark subclinical inflammation in Hashimoto's thyroiditis; leaves open its cardiovascular risk utility pending prospective studies.
Aim: Serum RDW grades were detected in patients with Hashimoto's thyroiditis. We aimed to use RDW to detect increased cardiovascular events in patients, increased oxidative stress, and inflammation without the need for an additional cost. Methods: We collected 904 persons results, 462 patients which have Hashimoto's thyroiditis, and 442 age and sex-matched control cases were comprised in our study. From laboratory measurements of the patients’ records were utilized such as hemogram, hs-CRP, fasting blood glucose, insulin, C-peptide, kidney function tests, liver function tests (ALT, AST), serum lipids (total cholesterol, triglyceride, HDL, LDL), anti-Tg, and anti-TPO, FT3, FT4, TSH levels. Results: RDW was considerably scaled up in case group compared to control group (Hashimoto's thyroiditis =10.08 ± 4.48%, control = 8.95 ± 6.68%, p <0.05). Also, MPV was increased in the study group(p<0.05). hs-CRP showed a statistically significant positive correlation between the level of RDW. Conclusion: Although the exact mechanism is still not fully understood, increased RDW levels in individuals with Hashimoto’s thyroiditis, possibly related to ongoing subclinical inflammation, neurohumoral activation, and changes resulting from oxidative stress in such patients. RDW is potentially a valuable tool for assessing cardiovascular diseases among patients diagnosed with Hashimoto's thyroiditis.
No takes yet. Share an insight, caveat, or question.
AYGÜN et al. (2023) conducted a case-control in Hashimoto's thyroiditis (n=904). Hashimoto's thyroiditis vs. Age and sex-matched controls without Hashimoto's thyroiditis was evaluated on Serum RDW level (%) (p=0.003). Patients with Hashimoto's thyroiditis had significantly higher serum RDW levels compared to controls (10.08% vs 8.95%, p=0.003), indicating potential subclinical inflammation.
Synapse has enriched 10 related papers. Consider them for comparative context: