What question did this study set out to answer?

To evaluate the association and discriminatory power of thyroid-stimulating hormone with key cardiovascular risk markers, including hs-CRP, atherogenic index of plasma, and HbA1c, in subclinical hypothyroidism.

June 1, 2026Biochemistry (Moscow) Supplement Series B Biomedical Chemistry

Predictive Value of TSH for Cardiovascular Risk Markers in Subclinical Hypothyroidism: Focus on CRP, AIP, and HbA1c

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Authors

AAAwat Hamad Awla FAFatima E. Ahmed WHWafa Ahmed Hamadameen

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Overview

Case-control study reveals elevated thyroid-stimulating hormone correlates with inflammation and atherogenic lipids in subclinical hypothyroidism, indicating early cardiovascular risk.

Key Points

To evaluate the association and discriminatory power of thyroid-stimulating hormone with key cardiovascular risk markers, including hs-CRP, atherogenic index of plasma, and HbA1c, in subclinical hypothyroidism.
Conducted a comparative case-control study enrolling 76 patients with subclinical hypothyroidism and 72 age- and sex-matched healthy controls.
Assessed biochemical markers including thyroid hormones (TSH, FT3, FT4), anti-TPO antibodies, lipid profiles, hs-CRP, atherogenic index of plasma (AIP), fasting glucose, and HbA1c.
Analyzed associations and predictive capacity using Spearman's correlation, multivariable binary logistic regression, and receiver operating characteristic (ROC) curves.
Patients with subclinical hypothyroidism had significantly higher total cholesterol, triglycerides, LDL, VLDL, and AIP than controls (p < 0.05), while HDL, fasting glucose, and HbA1c showed no significant differences.
TSH correlated positively with hs-CRP (r = 0.343, p = 0.002) and AIP (r = 0.235, p = 0.041), emerging as an independent predictor of hs-CRP in multiple regression analysis.
Multivariable adjustment improved the discriminatory performance of hs-CRP in ROC analysis, increasing the area under the curve from 0.747 to 0.838 (ΔAUC = 0.0906, p = 0.0227).

Cite This Study

Awla et al. (2026) studied this question.

synapsesocial.com/papers/6aa53a3e04ea443b843a496a https://doi.org/10.1134/s1990750826600081

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June 1, 2026Biochemistry (Moscow) Supplement Series B Biomedical Chemistry

Predictive Value of TSH for Cardiovascular Risk Markers in Subclinical Hypothyroidism: Focus on CRP, AIP, and HbA1c

View Full Paper

Ask AI

Bookmark

Authors

AAAwat Hamad Awla FAFatima E. Ahmed WHWafa Ahmed Hamadameen

Discussion

Member takes

Overview

Case-control study reveals elevated thyroid-stimulating hormone correlates with inflammation and atherogenic lipids in subclinical hypothyroidism, indicating early cardiovascular risk.

Key Points

To evaluate the association and discriminatory power of thyroid-stimulating hormone with key cardiovascular risk markers, including hs-CRP, atherogenic index of plasma, and HbA1c, in subclinical hypothyroidism.
Conducted a comparative case-control study enrolling 76 patients with subclinical hypothyroidism and 72 age- and sex-matched healthy controls.
Assessed biochemical markers including thyroid hormones (TSH, FT3, FT4), anti-TPO antibodies, lipid profiles, hs-CRP, atherogenic index of plasma (AIP), fasting glucose, and HbA1c.
Analyzed associations and predictive capacity using Spearman's correlation, multivariable binary logistic regression, and receiver operating characteristic (ROC) curves.
Patients with subclinical hypothyroidism had significantly higher total cholesterol, triglycerides, LDL, VLDL, and AIP than controls (p < 0.05), while HDL, fasting glucose, and HbA1c showed no significant differences.
TSH correlated positively with hs-CRP (r = 0.343, p = 0.002) and AIP (r = 0.235, p = 0.041), emerging as an independent predictor of hs-CRP in multiple regression analysis.
Multivariable adjustment improved the discriminatory performance of hs-CRP in ROC analysis, increasing the area under the curve from 0.747 to 0.838 (ΔAUC = 0.0906, p = 0.0227).

Cite This Study

Awla et al. (2026) studied this question.

synapsesocial.com/papers/6aa53a3e04ea443b843a496a https://doi.org/10.1134/s1990750826600081

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