November 1, 1983Circulation
The mechanism of transluminal angioplasty: evidence for formation of aneurysms in experimental atherosclerosis.
Key result
Transluminal angioplasty significantly increased luminal and total vessel areas compared to nondilated controls (p<0.05) through vessel stretching and localized aneurysm formation.
Why the study?
Does transluminal angioplasty cause compression of atheromatous material or stretching of the vessel in experimental atherosclerosis?
Population
Rabbit model with experimental atherosclerosis in both iliac arteries
Comparison
Transluminal angioplasty performed on the left… vs Right iliac artery serving as a nondilated control
Design
Preclinical
Authors
Discussion
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Implication
Supports vessel stretching over plaque compression in experimental models; leaves open translation to clinical angioplasty.
Structured PICO
Does transluminal angioplasty cause compression of atheromatous material or stretching of the vessel in experimental atherosclerosis?
P
Population
Rabbits with experimental atherosclerosis in both iliac arteries undergoing transluminal angioplasty on the left iliac artery.
I
Intervention
Transluminal angioplasty performed on the left iliac artery
C
Comparator
Right iliac artery serving as a nondilated control
O
Outcome
Quantitative histologic examination (morphometric analysis) of luminal, total vessel, and arterial wall areassurrogate
Main Result
p-value: p=<0.05
Transluminal angioplasty increases luminal area primarily through vessel stretching and localized aneurysm formation, with no evidence of atheromatous compression.
Cite This Study
Sanborn et al. (1983) studied Experimental atherosclerosis. Transluminal angioplasty vs. Nondilated control (right iliac artery) was evaluated on Luminal and total vessel areas (p=<0.05). Transluminal angioplasty significantly increased luminal and total vessel areas compared to nondilated controls (p<0.05) through vessel stretching and localized aneurysm formation.