Why the study?
Are GPIHBP1 mutations responsible for cases of severe hypertriglyceridemia in humans?
Are GPIHBP1 mutations responsible for cases of severe hypertriglyceridemia in humans?
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While GPIHBP1 is crucial for lipolytic processing of chylomicrons in mice, the clinical relevance of specific human mutations like G56R in severe hypertriglyceridemia remains uncertain.
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Bennett et al. (2008) studied this question.
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