Key result
The combination of 75 g of glucose and a 5-min mental stressor impaired endothelium-dependent dilatation at 30 minutes, whereas neither factor alone significantly changed endothelial function.
Why the study?
Does the combination of glucose and mental stress impair cutaneous microvascular endothelial function more than each factor alone in young, healthy females?
Does the combination of glucose and mental stress impair cutaneous microvascular endothelial function more than each factor alone in young, healthy females?
The combination of an acute glucose load and mental stress impairs microvascular endothelial function, suggesting that combined vascular risk factors are more detrimental to cardiovascular health than individual ones.
Combined glucose load and mental stress may impair microvascular endothelial function in healthy young women; hypothesis-generating for synergistic stressor effects.
Glucose and mental stress, independently, have been found to impair arterial endothelial function (an indicator of vascular health). The present study sought to determine whether the combination of glucose and stress would have a greater effect on microvascular endothelial function than each on its own. To assess endothelial function, surges in skin blood flow (reactive hyperemia), following the release of cuff pressure to the upper arm at 200 mmHg for 5 min, were measured with laser Doppler flowmetry in 40 young, healthy females. Endothelial function did not change significantly following a 5-min mathematics stressor or the consumption of 75 g of glucose. However, the combination of glucose and stress impaired endothelium-dependent dilatation 30 min after glucose consumption. These findings suggest that combinations of vascular risk factors may be more threatening to cardiovascular health than singularly occurring factors.
No takes yet. Share an insight, caveat, or question.
Brion et al. (2005) studied Healthy (n=40). Combination of glucose and mental stress vs. Glucose alone or mental stress alone was evaluated on Microvascular endothelial function (reactive hyperemia measured with laser Doppler flowmetry). The combination of 75 g of glucose and a 5-min mental stressor impaired endothelium-dependent dilatation at 30 minutes, whereas neither factor alone significantly changed endothelial function.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: