Key result
Intrarenal renin-angiotensin system activation plays a key pathophysiologic role in the development and progression of experimental glomerulonephritis.
Why the study?
What is the role of intrarenal renin-angiotensin system activation in the pathophysiology of experimental models of glomerulonephritis?
Population
Experimental models of glomerulonephritis (GN) and humans with various types of GN
Design
Review
Authors
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Does not inform clinical GN management; leaves open whether targeting intrarenal RAS improves outcomes beyond BP control in patients.
What is the role of intrarenal renin-angiotensin system activation in the pathophysiology of experimental models of glomerulonephritis?
Intrarenal RAS activation contributes to glomerular injury in glomerulonephritis, and its blockade with ACE inhibitors or ARBs offers renoprotective effects independent of blood pressure lowering.
Urushihara et al. (2012) conducted a review in Glomerulonephritis. Intrarenal renin-angiotensin system (RAS) activation was evaluated. Intrarenal renin-angiotensin system activation plays a key pathophysiologic role in the development and progression of experimental glomerulonephritis.
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