Two authors (D.B. and L.S.) independently extracted data. Discrepancies were resolved by discussion with C.P. as the final adjudicator. The data extracted were 1. inclusion criteria, 2. type(s) of data comparison/numbers of patients, 3. type(s) of intervention, drugs/doses, 4. time to treatment (TTT) from wake-up and LSW, 5. imaging findings, 6. stroke severity (baseline National Institute of Health Stroke Scale [NIHSS]), and 7. treatment outcomes: disability (modified Rankin Scale [mRS]), Barthel Index, mortality, asymptomatic brain hemorrhage, and symptomatic brain hemorrhage (SBH). Asymptomatic brain hemorrhage and SBH definitions varied (Table I in the onlineonly Data Supplement).
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Buck et al. (2014) studied this question.
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