Key points are not available for this paper at this time.
involved in trials like those of adrenocorticotrophic hormone and cortisone for the treatment of ulcerative colitis, and more centres became involved in the Medical Research Council's trials of treatment for different forms of leukaemia. 16 It was many years before randomisation was accepted as such a normal procedure. Only then did it become possible to organise the groundbreaking international study of infarct survival (ISIS) trials for the treatment of myocardial infarction, which involved hundreds of centres and randomly allocated tens of thousands of patients, and thereby showed the value of moderate improvements in the treatment of common diseases. 17 Without Bradford Hill, randomisation would have come about sooner or later, perhaps introduced by Rutstein in the United States. Rutstein collaborated with Bradford Hill in the design of an Anglo-American trial of adrenocorticotrophic hormone, cortisone, and aspirin in the treatment of acute rheumatic fever. 18 Randomisation would have been adopted much more slowly, however, without Bradford Hill's understanding of medical susceptibility and medical ethics and without his concern for simplicity of design and clarity of presentation. Modern authors please note.
Akira Yoshioka (Sat,) studied this question.