Key result
Moderately severe COPD was associated with reduced resting autonomic function compared to controls, specifically in mean RR intervals, LF, SD1, and ApEn (p < 0.05).
Why the study?
Does moderately severe COPD impair resting cardiac autonomic function and cardio-vagal reactivity in physically active subjects compared to matched controls?
Case-Control (n=48)
Does moderately severe COPD impair resting cardiac autonomic function and cardio-vagal reactivity in physically active subjects compared to matched controls?
Physically active patients with moderately severe COPD exhibit subtle resting cardiac autonomic impairments but maintain normal cardio-vagal reactivity compared to healthy controls.
Answers are grounded in this paper and cite their sources.
May indicate early autonomic changes in active moderate COPD; leaves open prognostic value and need for prospective studies.
Patients with chronic obstructive pulmonary disease (COPD) show impairments in the autonomic nervous systems (ANS) function, which is responsible for cardiac autonomic regulation. This study assessed the autonomic function and cardio-vagal reactivity in conveniently sampled subjects with COPD participating in a pulmonary rehabilitation (PR) program. Twenty-six subjects with COPD and 22 age and gender matched control subjects were evaluated. R-R intervals were collected at rest in supine position. Thereafter, resting autonomic function parameters comprising linear and nonlinear analyses of heart rate variability (HRV) and baroreceptor sensitivity (BRS) were calculated. Autonomic reactivity tests comprising deep breathing (DB), Valsalva maneuver (VM), and head up tilt (HUT) were also performed. The results of this study indicated that resting autonomic function variables were generally reduced in COPD compared to controls. However, this difference was only statistically significant for a few HRV parameters: mean RR intervals, low frequency (LF), standard deviation of dispersion of points perpendicular to the line-of-identity (SD1), and approximate entropy (ApEn) (p < 0.05). The results also indicated that all cardio-vagal indices following the autonomic reactivity tests were comparable between COPD and controls (p > 0.05). It was concluded that subtle autonomic impairments exists in physically active COPD patients, and these autonomic function deficits were mainly recognized by resting HRV indices and not autonomic reactivity tests.
No takes yet. Share an insight, caveat, or question.
Mohammed et al. (2018) conducted a case-control in Chronic obstructive pulmonary disease (COPD) (n=48). Moderately severe COPD vs. Age and gender matched control subjects was evaluated on Resting autonomic function parameters (HRV and BRS) and autonomic reactivity tests (p=< 0.05). Moderately severe COPD was associated with reduced resting autonomic function compared to controls, specifically in mean RR intervals, LF, SD1, and ApEn (p < 0.05).
Synapse has enriched 10 related papers. Consider them for comparative context: