February 3, 2007Stroke
Predictors of Carotid Intima-Media Thickness Progression in Young Adults
Key result
Smoking was a consistent predictor of short-term carotid intima-media thickness progression in both sexes, while traditional risk factors like systolic blood pressure predicted progression in men.
Population
336 young adults in the Bogalusa Heart Study, mean age 32.3+/-3.0 years
Design
Cohort
Follow-up
5.8+/-0.6 years
Authors
Discussion
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Implication
May support early smoking cessation in young adults; extends data on sex differences in atherosclerosis progression but requires trial confirmation.
Study Design
Type
Cohort (n=336)
Structured PICO
P
Population
336 young adults (mean age 32.3 years) from the Bogalusa Heart Study followed for a mean of 5.8 years to evaluate predictors of carotid intima-media thickness progression.
O
Outcome
Carotid intima-media thickness (CIMT) progression measured by B-mode ultrasound over 5.8+/-0.6 yearssurrogate
Main Result
Absolute Event Rate: 0.02% vs 0.015%
p-value: p=0.155
Smoking and traditional risk factors are significant predictors of subclinical atherosclerosis progression (measured by CIMT) even in young adults, emphasizing the need for early preventive strategies.
Cite This Study
Johnson et al. (2007) conducted a cohort in Subclinical atherosclerosis (n=336). Male sex and traditional cardiovascular risk factors (smoking, systolic blood pressure, fasting glucose) vs. Female sex and absence of risk factors was evaluated on Carotid intima-media thickness (CIMT) progression rate (mm/y) (p=0.155). Smoking was a consistent predictor of short-term carotid intima-media thickness progression in both sexes, while traditional risk factors like systolic blood pressure predicted progression in men.