Key result
Polycystic ovary syndrome was associated with a significantly higher prevalence of carotid plaque (plaque index ≥3) compared with controls (7.2% vs 0.7%, P=0.05).
Why the study?
Does polycystic ovary syndrome increase the risk of premature carotid atherosclerosis in middle-aged women?
Population
267 white women aged ≥30 years, including 125 with polycystic ovary syndrome and 142 age-matched controls.
Comparison
Polycystic ovary syndrome (PCOS) exposure vs Age-matched control subjects without PCOS
Design
Cohort
Follow-up
Baseline 1992-1994 to follow-up 1996-1999
Authors
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May support earlier vascular assessment in middle-aged women with PCOS; leaves open whether screening improves outcomes.
Case-Control (n=267)
Does polycystic ovary syndrome increase the risk of premature carotid atherosclerosis in middle-aged women?
Absolute Event Rate: 7.2% vs 0.7%
p-value: p=0.05
Women with PCOS, particularly those aged ≥45 years, exhibit increased carotid intima-media thickness and a higher prevalence of carotid plaque, indicating an elevated risk for premature atherosclerosis.
Talbott et al. (2000) conducted a case-control in Polycystic ovary syndrome (PCOS) (n=267). Polycystic ovary syndrome (PCOS) vs. Age-matched control subjects was evaluated on Plaque index of ≥3 (p=0.05). Polycystic ovary syndrome was associated with a significantly higher prevalence of carotid plaque (plaque index ≥3) compared with controls (7.2% vs 0.7%, P=0.05).
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