NK cell recovery after haploidentical HSCT with posttransplant cyclophosphamide: dynamics and clinical implications

Antonio Russo; Giacomo Oliveira; Sofia Berglund; Raffaella Greco; Valentina Gambacorta; Nicoletta Cieri; Cristina Toffalori; Laura Zito; Francesca Lorentino; Simona Piemontese; Mara Morelli; Fabio Giglio; Andrea Assanelli; Maria Teresa Lupo Stanghellini; Chiara Bonini; Jacopo Peccatori; Fabio Ciceri; Leo Luznik; Luca Vago

doi:10.1182/blood-2017-05-780668

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Abstract

Key Points Posttransplantation cyclophosphamide eliminates most mature donor NK cells infused with the graft, including alloreactive NK cells. High levels of serum interleukin-15 early after HSCT provide a favorable environment for adoptive infusion of mature donor NK cells.

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Russo et al. (2017) studied this question.

synapsesocial.com/papers/6a21b08184d1906bac5fdf7c https://doi.org/10.1182/blood-2017-05-780668

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NK cell recovery after haploidentical HSCT with posttransplant cyclophosphamide: dynamics and clinical implications

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Abstract

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NK cell recovery after haploidentical HSCT with posttransplant cyclophosphamide: dynamics and clinical implications

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