Key result
Vascular aging, driven by mechanisms such as the renin-angiotensin system, oxidative stress, and inflammation, plays a crucial role in the pathogenesis of age-related diseases including stroke and dementia.
This review outlines the molecular mechanisms of vascular aging, providing a foundation for potential diagnostic and therapeutic strategies for age-related vascular diseases.
Supports exploration of vascular-targeted therapies for stroke and dementia; leaves open clinical adoption pending randomized evidence.
As with many age-related diseases including vascular dysfunction, age is considered an independent and crucial risk factor. Complicated alterations of structure and function in the vasculature are linked with aging hence, understanding the underlying mechanisms of age-induced vascular pathophysiological changes holds possibilities for developing clinical diagnostic methods and new therapeutic strategies. Here, we discuss the underlying molecular mediators that could be involved in vascular aging, e.g., the renin-angiotensin system and pro-inflammatory factors, metalloproteinases, calpain-1, monocyte chemoattractant protein-1 (MCP-1) and TGFβ-1 as well as the potential roles of testosterone and estrogen. We then relate all of these to clinical manifestations such as vascular dementia and stroke in addition to reviewing the existing clinical measurements and potential interventions for age-related vascular dysfunction.
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Xu et al. (2017) conducted a review in Vascular aging. Vascular aging, driven by mechanisms such as the renin-angiotensin system, oxidative stress, and inflammation, plays a crucial role in the pathogenesis of age-related diseases including stroke and dementia.
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