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The concept of the "statistical significance" of an observation, and how it is used in particle physics experiments is reviewed. More properly known as a "p-value," the statistical foundations for this concept are reviewed from a freqentist perspective. The discovery of the top quark at the Fermilab Tevatron Collider and a more recent analysis of data recorded at Fermilab are used to illustrate practical applications of these concepts.
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P. Sinervo (2002) studied this question.