Key result
Plasma adenosine levels did not predict major adverse cardiovascular events in patients undergoing invasive angiography (low-to-high tertile HR 0.95; 95% CI 0.56-1.57; P=0.84).
Why the study?
Circulating adenosine showed promise in modulating vascular homeostasis and predicting cardiovascular events, but whether plasma levels predict events in patients undergoing invasive assessment for CAD required delineation.
Do circulating plasma adenosine levels predict major adverse cardiovascular events in patients undergoing invasive assessment for coronary artery disease?
Cohort (n=1,323)
Do circulating plasma adenosine levels predict major adverse cardiovascular events in patients undergoing invasive assessment for coronary artery disease?
Hazard Ratio: 0.95 (95% CI 0.56–1.57)
p-value: p=0.84
Plasma adenosine levels do not predict subsequent cardiovascular outcomes or aid in patient risk stratification in patients undergoing invasive angiography.
No takes yet. Share an insight, caveat, or question.
Does not support adenosine measurement for risk stratification in angiography patients; leaves open its prognostic role in other cohorts.
Simard et al. (2020) conducted a cohort in Coronary artery disease (n=1,323). Plasma adenosine levels vs. Low adenosine tertile was evaluated on Major adverse cardiovascular events (composite of death, myocardial infarction, unplanned revascularization, and cerebrovascular accident) (HR 0.95, 95% CI 0.56-1.57, p=0.84). Plasma adenosine levels did not predict major adverse cardiovascular events in patients undergoing invasive angiography (low-to-high tertile HR 0.95; 95% CI 0.56-1.57; P=0.84).
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