Intra-patient analysis of individual weight gain or loss between IVF cycles: cycle now and transfer later

November 24, 2023Human ReproductionOpen Access

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Key Points

This research assesses how changes in weight affect IVF cycle performance outcomes.
Retrospective within-patient analysis of 961 women undergoing at least two IVF cycles from 2014 to 2020.
Participants experienced short-term weight gain (n=607) or loss (n=354) within one year before their IVF cycles.
Multivariable generalized estimating equations (GEE) and generalized linear mixed models (GLMM) analyzed the relationship between weight change and IVF outcomes.
Weight loss did not significantly affect oocyte retrieval, fertilization, or blastulation rates.
Weight gain showed a minor positive association with the number of oocytes retrieved (coefficient: 0.01, 95% CI: 0.00-0.01).
A potential increase in fertilization rate was observed with weight gain (coefficient: 0.01, 95% CI: 0.00-0.02).

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Retrospective analysis evaluates weight change impact on IVF outcomes, suggesting timing should prioritize procedure over weight adjustment.

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Fouks et al. (2023) studied this question.

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