Key result
Coronary artery disease and type 2 diabetes mellitus were associated with significantly increased aortic pulse wave velocity compared to healthy controls (10.2 m/s and 9.7 m/s vs. 9.3 m/s, respectively).
Why the study?
Does arterial stiffness measured by an oscillometric device differ in patients with coronary artery disease or type 2 diabetes mellitus compared to healthy controls?
Cross-Sectional (n=524)
No
Does arterial stiffness measured by an oscillometric device differ in patients with coronary artery disease or type 2 diabetes mellitus compared to healthy controls?
Arterial stiffness parameters measured by an oscillometric device are significantly impaired in patients with CAD and T2DM, supporting their use in daily clinical routine for cardiovascular risk assessment.
Answers are grounded in this paper and cite their sources.
May indicate higher arterial stiffness in CAD and T2DM; leaves open whether oscillometric PWV adds value to risk stratification.
Recently an expert consensus document advised to standardize user procedures and a new cut-off value for carotid-femoral pulse wave velocity in daily practice. Our aim was to observe aortic pulse wave velocity (PWVao) and augmentation index (AIXao) in two high cardiovascular risk groups: patients with verified coronary artery disease (CAD) or with type 2 diabetes mellitus (T2DM). We also aimed to determine the cut-off values for PWVao, AIXao in CAD and T2DM patients using oscillometric device (Arteriograph). We investigated 186 CAD and 152 T2DM patients. PWVao and AIXao increased significantly in the CAD group compared to the age-, gender-, blood pressure-, and heart rate-matched control group (10.2+/-2.3 vs. 9.3+/-1.5 m/s; p<0.001 and 34.9+/-14.6 vs. 31.9+/-12.8 %; p<0.05, respectively). When compared to the apparently healthy control subjects, T2DM patients had significantly elevated PWVao (9.7+/-1.7 vs. 9.3+/-1.5 m/s; p<0.05, respectively), however the AIXao did not differ significantly. The ROC-curves of CAD and healthy control subjects explored cut-off values of 10.2 m/s for PWVao and 33.23 % for AIXao. Our data provide supporting evidence about impaired arterial stiffness parameters in CAD and T2DM. Our findings encourage the implementation of arterial stiffness measurements by oscillometric method in daily clinical routine.
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Lenkey et al. (2014) conducted a cross-sectional in Coronary Artery Disease and Type 2 Diabetes Mellitus (n=524). Coronary Artery Disease and Type 2 Diabetes Mellitus vs. Healthy controls was evaluated on Aortic pulse wave velocity (PWVao) in CAD patients vs controls (p=<0.001). Coronary artery disease and type 2 diabetes mellitus were associated with significantly increased aortic pulse wave velocity compared to healthy controls (10.2 m/s and 9.7 m/s vs. 9.3 m/s, respectively).
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