Arterial Stiffness Parameters in Patients With Moderate/High Cardiovascular Risk During Lisinopril and Simvastatin Treatment

Aim. To evaluate parameters of arterial stiffness by non-invasive arteriography in patients with moderate/high cardiovascular risk receiving lisinopril and simvastatin. Material and methods. 20 patients (aged 50-55 y.o.) with arterial hypertension of the 1st degree and dislipidemia are included in the study. All patients had pulse wave velocity (PWV) ≥ 10 m/s and/or the corrected index of pulse wave augmentation (AI × 80) ≥ -10% according to non-invasive arteriography data; and moderate-high cardiovascular risk (≥ 3%). Patients received therapy with lisinopril and simvastatin. Blood pressure (BP) levels and lipid profiles were assessed before therapy and in 1, 2, 6 and 12 month of the observation. Non-invasive arteriography was performed before therapy and in 2, 6 and 12 months later. Results. BP target levels were reached within 1 month of treatment as well as improvement of lipid profile was reached within 2 months in majority of the patients. Reference PWV and AI were reached in 85,7% of patients within one year of treatment. Conclusion. Arterial stiffness parameters help to evaluate cardiovascular risk changes accurately as the results of treatment.