Key result
Picornavirus infection rapidly activates import of long chain fatty acids, which are utilized for highly up-regulated phosphatidylcholine synthesis via cellular long chain acyl-CoA synthetase 3 (Acsl3).
Poliovirus reorganizes cellular lipid metabolism by targeting long chain acyl-CoA synthetase activity to build replication organelles from de novo synthesized membranes.
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Should not yet alter clinical practice; leaves open Acsl3 as an antiviral target in humans.
Nchoutmboube et al. (2013) studied Picornavirus infection. Picornavirus infection vs. Mock-infected cells was evaluated on Long chain fatty acid import and phosphatidylcholine synthesis. Picornavirus infection rapidly activates import of long chain fatty acids, which are utilized for highly up-regulated phosphatidylcholine synthesis via cellular long chain acyl-CoA synthetase 3 (Acsl3).
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