Key result
Simulations of electrical propagation in a rabbit ventricular tissue model showed that reducing conductivity alone in the infarct zone does not fully replicate experimentally observed wave propagation patterns.
Simple reduction of conductivity in computational models is insufficient to accurately replicate the complex electrical propagation patterns observed experimentally in infarcted ventricular tissue.
Simple conductivity reduction inadequately models infarct propagation; leaves open the need for heterogeneous remodeling parameters in arrhythmia simulations.
We report three-dimensional and time-dependent numerical simulations of the propagation of electrical action potentials in a model of rabbit ventricular tissue. The simulations are performed using a finite-element method for the solution of the monodomain equations of cardiac electrical excitation. The parameters of a detailed ionic ventricular cell model are re-fitted to available experimental data and the model is then used for the description of the transmembrane current and calcium dynamics. A region with reduced conductivity is introduced to model a myocardial infarction scar. Electrical activation times and density maps of the transmembrane voltage are computed and compared with experimental measurements in rabbit preparations with myocardial infarction obtained by a panoramic optical mapping method.
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Mortensen et al. (2021) studied Myocardial infarction (computational model). Reduced conductivity region (MI scar model) vs. Healthy tissue model was evaluated on Electrical activation times and transmembrane voltage density maps. Simulations of electrical propagation in a rabbit ventricular tissue model showed that reducing conductivity alone in the infarct zone does not fully replicate experimentally observed wave propagation patterns.
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