The functional role of electrophysiological heterogeneity in the rabbit ventricle during rapid pacing and arrhythmias
Key result
Incorporating intrinsic electrophysiological heterogeneity in a rabbit ventricular model facilitated arrhythmia initiation but played little functional role during sustained rapid arrhythmias.
Population
Biventricular rabbit computational model
Comparison
Incorporation of transmural and apicobasal… vs Equivalent homogeneous model
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Questions need to include electrophysiological heterogeneity in models of sustained arrhythmias; leaves open its role during initiation.
Structured PICO
P
Population
Biventricular rabbit computational model
I
Intervention
Incorporation of transmural and apicobasal action potential duration (APD) heterogeneity
C
Comparator
Equivalent homogeneous model
O
Outcome
Functional importance of intrinsic APD heterogeneity under fast pacing and arrhythmogenic protocols (arrhythmia initiation and sustained arrhythmia dynamics)surrogate
Intrinsic electrophysiological heterogeneity is important for arrhythmia initiation but plays little functional role during sustained arrhythmia dynamics in healthy ventricles, questioning the need for its inclusion in computational models of rapid arrhythmias.
Cite This Study
Bishop et al. (2013) studied Arrhythmias. Transmural and apicobasal action potential duration (APD) heterogeneity vs. Equivalent homogeneous model was evaluated on Arrhythmia initiation and sustained reentrant behavior. Incorporating intrinsic electrophysiological heterogeneity in a rabbit ventricular model facilitated arrhythmia initiation but played little functional role during sustained rapid arrhythmias.