Key result
Canine ventricular refractory periods were significantly shorter during drive of single ectopic sites and fusion drive compared to test site drive (P<0.005).
Why the study?
Does the driving mode affect ventricular refractory period duration in a canine model?
Population
Canine ventricular model
Comparison
Various driving modes vs Test site drive
Design
Preclinical
Authors
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Does not warrant clinical practice changes; leaves open translation of pacing-mode effects on refractoriness to humans.
Does the driving mode affect ventricular refractory period duration in a canine model?
p-value: p=<0.005
Ventricular refractory period duration is dependent on the driving mode, likely due to electrotonic interactions during repolarization.
Toyoshima et al. (1978) studied Ventricular repolarization (canine model). Ectopic and fusion drive modes vs. Test site drive was evaluated on Refractory period duration (p=<0.005). Canine ventricular refractory periods were significantly shorter during drive of single ectopic sites and fusion drive compared to test site drive (P<0.005).
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