What is the clinical evidence from this study?

Study design: Observational. Population: Right-sided cardiac thrombus (n=97). Intervention: Anticoagulation. Primary outcome: Survival (HR 0.25, 95% CI 0.09-0.68).

What question did this study set out to answer?

This research aims to describe clinical characteristics, treatments, and long-term outcomes of patients with right-sided cardiac thrombus.

August 17, 2022Hellenic Journal of CardiologyOpen Access

Clinical characteristics, treatment and long-term outcomes of patients with right-sided cardiac thrombus

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Key result

Anticoagulation (HR 0.25; 95% CI 0.09-0.68) and thrombus resolution (HR 0.28; 95% CI 0.13-0.62) were associated with greater survival in patients with right-sided cardiac thrombus.

Why the study?

Right-sided cardiac thrombus is rare with potentially life-threatening complications, but current data are limited and mostly derived from case series and pulmonary embolism registries.

Does anticoagulation improve survival in patients with right-sided cardiac thrombus?

Key Points

This research aims to describe clinical characteristics, treatments, and long-term outcomes of patients with right-sided cardiac thrombus.
Retrospective observational study analyzing 97 patients with right-sided cardiac thrombus detected via echocardiography.
Examined co-morbidities, predisposing factors, thrombus characteristics, and therapeutic interventions.
Assessed associations with complications like pulmonary embolism, paradoxical stroke, and all-cause mortality.
Mean age of participants was 58.7 years, with 56.7% being female.
Anticoagulation associated with greater survival (HR 0.25, 95% CI 0.09-0.68) and thrombus resolution also linked to improved survival (HR 0.28, 95% CI 0.13-0.62).
Thrombus mobility was linked to greater short-term mortality, but did not affect embolic events.

Study Design

Type

Observational (n=97)

Structured PICO

Does anticoagulation improve survival in patients with right-sided cardiac thrombus?

Population

97 consecutive patients (mean age 58.7 years, 56.7% female) with right-sided cardiac thrombus detected on echocardiography.

Exposure

Anticoagulation and therapeutic interventions for thrombus resolution

Comparator

No anticoagulation / no thrombus resolution

Outcome

Development of pulmonary embolism (PE), paradoxical stroke, circulatory collapse, and all-cause mortalityhard clinical

Main Result

Hazard Ratio: 0.25 (95% CI 0.09–0.68)

In patients with right-sided cardiac thrombus, anticoagulation and successful thrombus resolution are associated with significantly improved survival.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports anticoagulation consideration in right-sided thrombus; hypothesis-generating and requires randomized trials to confirm benefit.

Cite This Study

Goh et al. (2022) conducted an observational in Right-sided cardiac thrombus (n=97). Anticoagulation was evaluated on Survival (HR 0.25, 95% CI 0.09-0.68). Anticoagulation (HR 0.25; 95% CI 0.09-0.68) and thrombus resolution (HR 0.28; 95% CI 0.13-0.62) were associated with greater survival in patients with right-sided cardiac thrombus.

synapsesocial.com/papers/6a21be8a0831bdc6cec003fe https://doi.org/10.1016/j.hjc.2022.07.008

Topics

Atrial fibrillation Cardiomyopathy Pulmonary embolism Echocardiography Persistent AF management

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Clinical characteristics, treatment and long-term outcomes of patients with right-sided cardiac thrombus

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Topics

Clinical characteristics, treatment and long-term outcomes of patients with right-sided cardiac thrombus

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider