In a meta-analysis of 1,615 patients with left ventricular thrombus, DOACs showed no significant difference compared to VKAs for embolic events (OR 1.24; 95% CI 0.90-1.69).
Meta-Analysis (n=1,615)
Yes
Do direct oral anticoagulants (DOACs) provide similar safety and efficacy compared to vitamin K antagonists (VKAs) in patients with left ventricular thrombus?
DOACs appear to have similar efficacy and safety compared to VKAs for the treatment of left ventricular thrombus, suggesting they may be a reasonable alternative to traditional VKA therapy.
Odds Ratio: 1.24 (95% CI 0.9–1.69)
Aim: To compare the safety and efficacy of direct oral anticoagulants (DOAC) relative to vitamin K antagonists (VKA) for the treatment of left ventricular thrombus (LVT). Methods: This retrospective study enrolled patients diagnosed with LVT from 2014-2017. Patient characteristics and outcomes within 12 months of LVT diagnosis were recorded and analyzed. A meta-analysis was also performed by pooling our results with existing data in literature. Results: 14 DOAC and 59 VKA patients were included. Baseline demographic and clinical characteristics were similar except for age. Although more strokes within 12 months occurred in VKA (15%) than in DOAC (0%) patients, this was not statistically significant ( P = 0.189). There were no significant differences in outcomes between patients on DOAC and VKA for acute coronary syndrome (ACS) (7%, vs 3.4%, P = .477), LVT resolution (86% vs 76%, P = .499) or bleeding (14% vs 14%, P = 1) within 12 months. The meta-analysis included 6 studies (n = 408 for DOACs; n = 1207 for VKA). There were no significant differences between DOACs versus VKAs with respect to odds for unresolved thrombus (OR 0.61, 95% CI 0.26,1.41), embolic events (OR 1.24, 95% CI 0.90,1.69), embolic events and death (OR 1.10, 95% CI 0.84,1.45) or bleeding events (OR 1.13, 95% CI 0.74,1.72). Conclusions: Our study and meta-analysis suggest similar efficacy and safety of DOACs in the treatment of LVT compared to VKA. These findings underscore the need for a randomized controlled trial.
Cochran et al. (Tue,) conducted a meta-analysis in Left ventricular thrombus (LVT) (n=1,615). Direct oral anticoagulants (DOAC) vs. Vitamin K antagonists (VKA) was evaluated on Embolic events (OR 1.24, 95% CI 0.90-1.69). In a meta-analysis of 1,615 patients with left ventricular thrombus, DOACs showed no significant difference compared to VKAs for embolic events (OR 1.24; 95% CI 0.90-1.69).