Key result
A review of case reports suggests direct oral anticoagulants (DOACs) are emerging as potential alternatives to warfarin for treating left ventricular thrombus, though randomized trials are lacking.
Why the study?
Guidelines recommend warfarin for left ventricular thrombus, but DOACs are increasingly used despite the lack of randomized controlled trials proving their efficacy.
Do direct oral anticoagulants (DOACs) improve outcomes in patients with left ventricular thrombus compared to warfarin?
Do direct oral anticoagulants (DOACs) improve outcomes in patients with left ventricular thrombus compared to warfarin?
Emerging evidence from case reports suggests DOACs may be an effective and safe alternative to guideline-recommended warfarin for treating left ventricular thrombus.
Case reports leave open DOACs as alternatives to warfarin for LV thrombus; randomized trials required before any practice change.
: Left ventricular thrombus (LVT) is a commonly seen complication of myocardial infarction and it also can be seen because of hypertrophic cardiomyopathies, nonischemic dilated cardiomyopathies, malignancies, and so on. Guidelines suggest the use of warfarin for left ventricular thrombi, but recent case reports show that direct oral anticoagulants (DOACs) are beginning to be used for this complication. DOACs are strong alternatives for warfarin because of their efficacy and safety even though there is no randomized controlled trial that proves the effect of DOACs against LVT. In this article, we gather the case reports of DOACs against left ventricular thrombi in various conditions.
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Yıldırım et al. (2019) conducted a review in Left ventricular thrombus (LVT). Direct oral anticoagulants (DOACs) vs. Warfarin was evaluated. A review of case reports suggests direct oral anticoagulants (DOACs) are emerging as potential alternatives to warfarin for treating left ventricular thrombus, though randomized trials are lacking.
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