March 15, 2003Clinical Infectious DiseasesOpen Access

Symptom Severity Patterns in Experimental Common Colds and Their Usefulness in Timing Onset of Illness in Natural Colds

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Common cold. Intervention: Compensated natural cold treatment trials vs. Experimental colds and noncompensated natural colds. Primary outcome: Mean total symptom severity scores and peak timing.

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Key result

Compensated patients in natural cold treatment trials report inaccurate illness onset histories, with day 1 symptom scores matching 48-hour experimental cold scores.

Why the study?

Are histories regarding the onset of illness given by compensated patients in natural cold treatment trials accurate compared to experimental and noncompensated natural colds?

Population

Subjects with experimental rhinovirus colds, patients with natural rhinovirus and nonrhinovirus colds in a…

Comparison

Experimental rhinovirus inoculation and… vs Compensated patients receiving placebo in…

Authors

JGJack M. GwaltneyRutgers, The State University of New Jersey JHJ. Owen HendleyVirginia Department of Education JPJames T. PatriePennington Biomedical Research Center

Discussion

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Implication

Inaccurate compensated patient histories may bias natural cold trial efficacy estimates; leaves open need for objective onset verification in future studies.

Study Design

Type

Observational

Structured PICO

Are histories regarding the onset of illness given by compensated patients in natural cold treatment trials accurate compared to experimental and noncompensated natural colds?

Population

Subjects with experimental rhinovirus colds, patients with natural rhinovirus and nonrhinovirus colds in a noncompensated epidemiology study, and compensated patients receiving placebo in natural cold treatment trials

Exposure

Experimental rhinovirus inoculation and noncompensated natural colds

Comparator

Compensated patients receiving placebo in natural cold treatment trials

Outcome

Mean total symptom severity scores and timing of peak symptomspatient reported

Histories given by compensated patients in natural cold treatment trials are inaccurate regarding the onset and duration of illness.

Cite This Study

Gwaltney et al. (2003) conducted an observational in Common cold. Compensated natural cold treatment trials vs. Experimental colds and noncompensated natural colds was evaluated on Mean total symptom severity scores and peak timing. Compensated patients in natural cold treatment trials report inaccurate illness onset histories, with day 1 symptom scores matching 48-hour experimental cold scores.

synapsesocial.com/papers/6a21bea140227a3dcbc0affc https://doi.org/10.1086/367844

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Implication

Inaccurate compensated patient histories may bias natural cold trial efficacy estimates; leaves open need for objective onset verification in future studies.

Symptom Severity Patterns in Experimental Common Colds and Their Usefulness in Timing Onset of Illness in Natural Colds

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Symptom Severity Patterns in Experimental Common Colds and Their Usefulness in Timing Onset of Illness in Natural Colds

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider