Key result
Anaemia was associated with a higher risk of all-cause mortality and cardiovascular hospital admission among elderly patients with chronic heart failure (HR 1.47; 95% CI 1.18-1.82; P<0.001).
Why the study?
Does nebivolol affect the development of anaemia in elderly patients with chronic heart failure?
RCT (n=2,069)
randomized
Does nebivolol affect the development of anaemia in elderly patients with chronic heart failure?
Hazard Ratio: 1.47 (95% CI 1.18–1.82)
Absolute Event Rate: 41.9% vs 31.2%
p-value: p=<0.001
Anaemia is an independent predictor of death or cardiovascular hospitalization in elderly patients with chronic heart failure across the spectrum of ejection fraction, and haemoglobin levels are not affected by nebivolol.
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Anaemia signals elevated risk of death or CV admission in elderly HF regardless of LVEF; leaves open whether correction alters prognosis.
Haehling et al. (2011) conducted an RCT in Heart failure with preserved or reduced ejection fraction (n=2,069). Anaemia vs. No anaemia was evaluated on all-cause mortality and cardiovascular hospital admission (HR 1.47, 95% CI 1.18-1.82, p=<0.001). Anaemia was associated with a higher risk of all-cause mortality and cardiovascular hospital admission among elderly patients with chronic heart failure (HR 1.47; 95% CI 1.18-1.82; P<0.001).
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