Key result
A likely pathogenic variant in the titin (TTN) gene was identified in a patient with short-coupled premature ventricular complex-triggered ventricular fibrillation.
Why the study?
The genetic substrate of short-coupled premature ventricular complex-induced ventricular fibrillation is heterogeneous and remains incompletely defined.
Case Report (n=1)
Identifies a potential genetic link between a titin (TTN) gene variant and short-coupled PVC-triggered ventricular fibrillation.
Answers are grounded in this paper and cite their sources.
Does not alter management of short-coupled PVC-triggered VF; leaves open a potential TTN association requiring validation.
Ventricular fibrillation induced by short-coupled premature ventricular complex is an uncommon cause of cardiac arrest in young individuals with no structural heart disease. The genetic substrate of this condition is heterogeneous and remains incompletely defined. We describe a case of short-coupled premature ventricular complex–triggered ventricular fibrillation with a likely pathogenic variant in the titin (TTN) gene. (Level of Difficulty: Advanced.)
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Sikdar et al. (2022) conducted a case report in Short-coupled premature ventricular complex-triggered ventricular fibrillation (n=1). Likely pathogenic variant in the titin (TTN) gene was evaluated. A likely pathogenic variant in the titin (TTN) gene was identified in a patient with short-coupled premature ventricular complex-triggered ventricular fibrillation.
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