Key result
Closed-chest ablation of the His bundle resulted in severe histologic damage to the nearby AV node and penetrating His bundle, with no damage to the branching His bundle or bundle branches.
Why the study?
What are the histologic effects of closed-chest ablation of the His bundle on the atrioventricular conduction system?
Case Report (n=1)
What are the histologic effects of closed-chest ablation of the His bundle on the atrioventricular conduction system?
Closed-chest ablation of the His bundle causes severe localized damage to the AV node and penetrating His bundle without affecting the branching His bundle or bundle branches.
Answers are grounded in this paper and cite their sources.
Single-case histology indicates localized AV nodal injury from closed-chest His ablation; leaves open broader applicability and safety in clinical practice.
Postmortem examination of the heart was done in a case with disabling supraventricular tachyarrhythmia successfully treated by closed-chest ablation of the His bundle. A ventricular aneurysm developed as a result of a previous myocardial infarction, and death occurred suddenly five months after the procedure. Histologic studies of the atrioventricular (AV) junctional tissue demonstrated severe damage to the nearby AV node and penetrating His bundle. No damage to the branching His bundle or either bundle branch was observed.
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G Critelli (1984) conducted a case report in Disabling supraventricular tachyarrhythmia (n=1). Closed-chest ablation of the His bundle was evaluated on Histologic observations of the atrioventricular junctional tissue. Closed-chest ablation of the His bundle resulted in severe histologic damage to the nearby AV node and penetrating His bundle, with no damage to the branching His bundle or bundle branches.
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