Key result
Post-TAVR gastrointestinal bleeding occurs in ~3% of patients across randomized controlled trials.
Why the study?
Major bleeding after TAVR significantly increases morbidity and mortality, presenting management challenges when patients require post-procedure anticoagulation or antiplatelet therapy.
What is the incidence of gastrointestinal bleeding following transcatheter aortic valve replacement?
Systematic Review (n=8,731)
What is the incidence of gastrointestinal bleeding following transcatheter aortic valve replacement?
Absolute Event Rate: 3% vs 1.9%
Gastrointestinal bleeding occurs in 1.9% to 3.0% of patients following TAVR, complicating post-procedural antithrombotic management and requiring individualized care.
Supports individualized antithrombotic management post-TAVR to address bleeding risk; extends pooled incidence estimates across RCTs and observational studies.
BACKGROUND: There is a significant increase in morbidity and mortality in patients complicated by major bleeding following transcatheter aortic valve replacement (TAVR). It has become more challenging to manage such complications when the patient needs to be on anticoagulation or antiplatelet agent post-procedure to prevent thrombotic/embolic complications. METHODS: We systematically reviewed all available randomized controlled trials and observational studies to identify incidence rates of gastrointestinal bleeding post-procedure. After performing a systematic search, a total of 8731 patients from 15 studies (5 RCTs and 10 non-RCTs) were included in this review. RESULTS: The average rate of gastrointestinal bleeding during follow-up was 3.0% in randomized controlled trials and 1.9% among observational studies. CONCLUSION: Gastrointestinal bleeding has been noted to be higher in the RCTs as compared to observational studies. This review expands knowledge of current guidelines and possible management of patients undergoing TAVR.
No takes yet. Share an insight, caveat, or question.
Doshi et al. (2022) conducted a systematic review in Aortic stenosis undergoing TAVR (n=8,731). Transcatheter Aortic Valve Replacement (TAVR) was evaluated on Incidence of gastrointestinal bleeding. Transcatheter Aortic Valve Replacement was associated with an average post-procedure gastrointestinal bleeding incidence of 3.0% in randomized controlled trials and 1.9% in observational studies.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: