Key result
Angiotensin II-induced vascular smooth muscle cell gene transcription is mediated by GIT1 via a Src-PLCgamma-CamK II-HDAC5 signaling pathway.
Population
Vascular smooth muscle cells (VSMCs)
Design
Preclinical
Authors
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Hypothesis-generating for GIT1 in vascular remodeling; leaves open clinical translation to human hypertension.
GIT1 mediates Angiotensin II-induced vascular smooth muscle cell gene transcription through a Src-PLCgamma-CamK II-HDAC5 signaling pathway.
Pang et al. (2008) studied Angiotensin II signaling in vascular smooth muscle cells. Angiotensin II stimulation and GIT1 knockdown was evaluated on HDAC5 phosphorylation and MEF2 transcriptional activity. Angiotensin II-induced vascular smooth muscle cell gene transcription is mediated by GIT1 via a Src-PLCgamma-CamK II-HDAC5 signaling pathway.
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