Key result
ARNI linked to ~17% lower risk of new-onset dementia versus RASI in HF patients.
Why the study?
The study evaluated the impact of ARNI versus RASI on the risk and management of dementia among patients with heart failure.
Does ARNI reduce the risk of new-onset dementia in patients with heart failure compared to RASI?
Cohort (n=18,154)
Yes
Does ARNI reduce the risk of new-onset dementia in patients with heart failure compared to RASI?
In patients with heart failure, the use of ARNI is associated with a significantly lower risk of new-onset dementia compared to RASI therapy.
The authors report the impact of angiotensin receptor-neprilysin inhibitor (ARNI) versus renin-angiotensin system inhibitor (RASI) on the management and outcomes in dementia among heart failure (HF) patients as obtained from the real-life nationwide registry. In this study, HF patients between January 1, 2017 and December 31, 2019 were divided into 2 groups, including subjects receiving RASI and ARNI. The incidence rate of dementia was calculated with the unit of 1000 person-years. Cox proportional hazard model was applied for the examination of the hazard ratio, and also presented with 95% confidence interval. Between 2017 and 2019, RASI and ARNI cohorts contain 18,154 subjects. After adjusting with age, sex, comorbidities, and medications, ARNI cohort had a lower risk of dementia (adjusted hazard ratio = 0.83; 95% confidence interval = 0.72, 0.95) than RASI cohort. The authors concluded that use of ARNI was associated with a lower risk of new-onset dementia in patients with HF.
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Hu et al. (2023) conducted a cohort in Heart failure (n=18,154). Angiotensin receptor-neprilysin inhibitor (ARNI) vs. Renin-angiotensin system inhibitor (RASI) was evaluated on New-onset dementia (HR 0.83, 95% CI 0.72-0.95). Angiotensin receptor-neprilysin inhibitors (ARNI) were associated with a lower risk of new-onset dementia compared to RASI in patients with heart failure (HR 0.83; 95% CI 0.72-0.95).
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