Key result
Symptomatic atherosclerosis was associated with a denser network of vasa vasorum (33±2 vs 25±2 microvessels/mm2; P=0.008) and higher intimal macrophage content compared to asymptomatic disease.
Why the study?
Are arterial inflammation and neovascularization increased throughout the arterial tree in patients with symptomatic atherosclerosis compared to asymptomatic patients?
Population
49 postmortem patients, including 22 with symptomatic atherosclerosis and 27 who never suffered from…
Design
Case-control
Authors
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Supports viewing symptomatic atherosclerosis as panarterial; extends prior observations but remains hypothesis-generating.
Observational (n=49)
Are arterial inflammation and neovascularization increased throughout the arterial tree in patients with symptomatic atherosclerosis compared to asymptomatic patients?
Absolute Event Rate: 33% vs 25%
p-value: p=0.008
Symptomatic atherosclerosis is characterized by increased intimal macrophage content and hyperplastic vasa vasorum across multiple arterial beds, supporting its nature as a panarterial disease.
Fleiner et al. (2004) conducted an observational in Atherosclerosis (n=49). Symptomatic atherosclerosis vs. Asymptomatic atherosclerosis was evaluated on Adventitial microvessel density (vasa vasorum per 1 mm2) (p=0.008). Symptomatic atherosclerosis was associated with a denser network of vasa vasorum (33±2 vs 25±2 microvessels/mm2; P=0.008) and higher intimal macrophage content compared to asymptomatic disease.
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