Key result
Cardiac autonomic responses to stress predict future metabolic abnormalities, with greater parasympathetic withdrawal increasing burden in men and dampened responses increasing burden in women.
Why the study?
Do physiological responses to stress predict future metabolic burden in healthy men and women?
Cohort (n=199)
Do physiological responses to stress predict future metabolic burden in healthy men and women?
Cardiac autonomic responses to stress predict future metabolic abnormalities, with sex-specific differences in the direction of the effect.
May flag sex-specific metabolic risk via autonomic stress responses; leaves open causal pathways and prevention targets.
BACKGROUND: Heightened or prolonged physiological responses to stress may contribute to the development or progression of metabolic abnormalities. PURPOSE: This study aims to examine the prospective relationships between stress responses and metabolic burden, and to determine whether age and/or sex moderate these relationships. METHODS: One hundred ninety-nine healthy men and women (M(age) = 41 ± 11.5) were exposed to four stressors while blood pressure, heart rate, and heart rate variability were obtained. Residual change scores for reactivity (stress - baseline) and recovery (post-stress - baseline) scores were computed. Metabolic burden refers to the number of metabolic parameters for which participants were in the highest quartile (lowest for high-density lipoprotein cholesterol) for their sex. Metabolic burden was reassessed in 136 participants 3 years later. RESULTS: Greater parasympathetic withdrawal in response to stress was associated with increased metabolic burden, though this was evident mostly in men. In women, dampened autonomic responses to stress were associated with higher metabolic burden. CONCLUSIONS: Cardiac autonomic responses to stress predict future metabolic abnormalities, though the direction of effect differs according to sex.
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Gentile et al. (2014) conducted a cohort in Healthy (n=199). Physiological responses to stress was evaluated on Metabolic burden (number of metabolic parameters in highest quartile). Cardiac autonomic responses to stress predict future metabolic abnormalities, with greater parasympathetic withdrawal increasing burden in men and dampened responses increasing burden in women.
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