Key result
Abnormal CAVI is linked to ~5.3-fold higher odds of elevated cholesterol in metabolic syndrome.
Why the study?
Does metabolic syndrome alter the relationship between arterial stiffness parameters and lipid profiles in adults aged 40-70?
Cross-Sectional (n=100)
No
Does metabolic syndrome alter the relationship between arterial stiffness parameters and lipid profiles in adults aged 40-70?
CAVI may be a more sensitive indicator of arterial stiffness alterations linked to dyslipidemia and obesity in metabolic syndrome than traditional cfPWV measurements.
Answers are grounded in this paper and cite their sources.
Supports CAVI over cfPWV for lipid-linked stiffness in metabolic syndrome; hypothesis-generating and should not yet change practice.
Aim: to elucidate relationships between parameters of arterial stiffness (carotid-femoral pulse wave velocity [cfPWV] and cardio-ankle vascular index [CAVI]) and standard lipid profile parameters in patients with metabolic syndrome (MS). Materials. We included in this study 100 subjects (45 men, 55 women) aged 40-70 (mean 56.54±8.98) years with (n=42, group 1) or without (n=58, group 2) MS. Methods: Calculations of CAVI and cfPWV were fulfilled by computer sphygmography. In analysis we used threshold values recommended by manufacturers and European expert consensus document on arterial stiffness: for CAVI - <8, for cfPWV - ≤10 m/c). Blood serum levels of lipid profile components - total (T) cholesterol (C), low density lipoprotein C (LDLC- 3.0 mmol/l), high density lipoprotein C (HDLC), triglycerides (TG) were determined on biochemical automatic analyzer. Normal values: TC - 5.0, LDLC - 3.0, HDLC men -1.0, HDLC women -1.2, TG -1.7 mmol/l. Results. In group 1 we found statistically significant correlations between CAVI and TC (hazard ratio [HR] 5.26, 95% confidence interval [CI] 1.08-29.18, p=0.039), CAVI and LDLC (HR=6.88, 95% CI 1.35-40.99, p=0.034), CAVI and body mass index (BMI) (HR=8.42, 95% CI 1.04-22.11, p=0.044), CAVI and waist circumference (WC) (HR=14.02, 95% CI 1.34-74.7, p=0.021), and also between cfPWV and pulse pressure (PP) (HR=6.73, 95% CI 1.17-52.70, p=0.029). In the group 2 we found no statistically significant correlations between CAVI or cfPWV and lipid profile parameters. Conclusions. Among subjects without MS we found no significant correlations between characteristics of arterial stiffness (CAVI and cfPWV) and parameters of lipid profile. Among patients with metabolic syndrome we found significant correlations between CAVI and TC, LDLC, as well as BMI and WC. But there we no significant correlations between cfPWV and lipid profile parameters.
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Urazalina et al. (2018) conducted a cross-sectional in Metabolic Syndrome (n=100). Metabolic syndrome vs. Without metabolic syndrome was evaluated on Correlation between Cardio-Ankle Vascular Index (CAVI) and total cholesterol (TC) in patients with metabolic syndrome (OR 5.26, 95% CI 1.08-29.18, p=0.039). Among patients with metabolic syndrome, there was a significant association between the Cardio-Ankle Vascular Index (CAVI) and total cholesterol (OR 5.26) as well as LDL cholesterol, whereas no such correlations were found for carotid-femoral pulse wave velocity (cfPWV).
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