Key result
In patients with metabolic syndrome, the Cardio-Ankle Vascular Index (CAVI) was significantly associated with increased carotid intima-media thickness (OR 4.94) and the presence of carotid plaques.
Why the study?
Metabolic syndrome increases arterial stiffness, and early detection of increased stiffness could help prevent cardiovascular complications, but the relationship of cfPWV and CAVI with carotid atherosclerosis indicators needed evaluation.
Do arterial stiffness parameters (CAVI and cfPWV) correlate with carotid atherosclerosis indicators in patients with metabolic syndrome?
Cross-Sectional (n=100)
Open-label
No
Do arterial stiffness parameters (CAVI and cfPWV) correlate with carotid atherosclerosis indicators in patients with metabolic syndrome?
CAVI may be a useful parameter to identify subclinical signs of carotid atherosclerosis in patients with metabolic syndrome, outperforming cfPWV.
Answers are grounded in this paper and cite their sources.
CAVI association with carotid markers in metabolic syndrome is hypothesis-generating; prospective studies needed before clinical adoption.
Background: Many studies have shown that metabolic syndrome is accompanied by an increase in arterial stiffness. In connection therewith, early detection of an increase in arterial stiffness in patients with metabolic syndrome can help to prevent cardiovascular complications. Aim: To determine the relationship between arterial stiffness parameters such as cfPWV and CAVI with carotid atherosclerosis indicators (intima-media thickness, carotid plaque presence) in patients with metabolic syndrome. Material and methods: The study included 100 patients at the age of 40-70 years: 45 men and 55 women (56.54±8.98 years). Subjects were divided into 2 groups: 1st - 42 patients with metabolic syndrome; 2nd - 58 patients without metabolic syndrome. The arterial stiffness parameters such as CAVI and cfPWV were calculated. In the analysis we used threshold values recommended by manufacturers and European expert consensus document on arterial stiffness: for CAVI – <8, for cfPWV – ≤10 m/c). Duplex scanning carotid arteries was performed to evaluate the “intima-media thickness” and carotid plaque presence. Results: In the group with metabolic syndrome the CAVI is significantly associated with the indicators of carotid atherosclerosis: intima-media thickness (OR=4.94 95%; CI: 1.49-3.80; p=0.047), carotid plaque presence (OR=3.06; 95% CI: 1.42-2.28; p=0.065). But statistically significant associations of cfPWV with indicators of carotid atherosclerosis were not obtained (p>0.05). In the group without metabolic syndrome none of the arterial stiffness parameters (CAVI, cfPWV) statistically significantly correlated with any of the carotid atherosclerosis indicators (p>0.05). Conclusion: The CAVI parameter, in contrast to the cfPWV, statistically significantly correlated with indicators of carotid atherosclerosis in patients with metabolic syndrome. In this connection, this parameter can be used to identify signs of not only increased arterial stiffness but also to determine subclinical signs of carotid atherosclerosis in patients with metabolic syndrome.
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Urazalina et al. (2020) conducted a cross-sectional in Metabolic Syndrome (n=100). Cardio-Ankle Vascular Index (CAVI) vs. Carotid-femoral Pulse Wave Velocity (cfPWV) was evaluated on Association with increased carotid intima-media thickness (>0.9 mm) (OR 4.94, 95% CI 1.49-3.80, p=0.047). In patients with metabolic syndrome, the Cardio-Ankle Vascular Index (CAVI) was significantly associated with increased carotid intima-media thickness (OR 4.94) and the presence of carotid plaques.
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