Key result
In acute ischaemic stroke patients, arterial stiffness was independently associated with higher serum ESR (P=0.002) but not with metabolic syndrome (P=0.139) in multivariate analysis.
Why the study?
Is arterial stiffness associated with metabolic syndrome and inflammation in Asian ischemic stroke patients?
Observational (n=229)
Is arterial stiffness associated with metabolic syndrome and inflammation in Asian ischemic stroke patients?
p-value: p=0.002
Arterial stiffness is associated with metabolic syndrome in ischemic stroke patients, a relationship that appears to be driven by underlying inflammation.
Arterial stiffness was associated with ESR but not metabolic syndrome in acute ischemic stroke; leaves open inflammation's mediating role pending prospective confirmation.
BACKGROUND AND PURPOSE: Arterial stiffness and metabolic syndrome (MetS) are risk factors for ischaemic stroke. We studied the association of arterial stiffness, measured by carotid-femoral pulse wave velocity (PWV) and MetS amongst ischaemic stroke patients. We also investigated the role of inflammation measured by serum erythrocyte sedimentation rate (ESR) in the metabolic syndrome-arterial stiffness relationship. METHODS: Amongst the 229 prospectively recruited acute ischaemic stroke patients, we measured carotid-femoral PWV using applanation tonometry and the inflammatory marker serum ESR. RESULTS: Carotid-femoral PWV was significantly higher amongst patients with MetS (P = 0.002), increased waist circumference (P = 0.010), raised blood pressure (P < 0.001) and abnormal glycemia (P = 0.002); and increased with the number of MetS components (P = 0.002). In a sub-group of 199 patients, carotid-femoral PWV was significantly correlated with serum ESR (P < 0.001). In multivariate regression analysis including serum ESR and MetS as variables, carotid-femoral PWV was independently associated with higher ESR (P = 0.002) but not with MetS (P = 0.139). CONCLUSIONS: Arterial stiffness is significantly associated with MetS amongst ischaemic stroke patients, and inflammation appears to be involved in this relationship.
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Silva et al. (2008) conducted an observational in acute ischaemic stroke (n=229). Metabolic syndrome and inflammation (serum ESR) vs. Absence of metabolic syndrome / lower ESR was evaluated on Arterial stiffness measured by carotid-femoral pulse wave velocity (PWV) (p=0.002). In acute ischaemic stroke patients, arterial stiffness was independently associated with higher serum ESR (P=0.002) but not with metabolic syndrome (P=0.139) in multivariate analysis.
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