Patients with metabolic syndrome had significantly increased pulse wave velocity compared to controls (7.8 vs. 7.0 m/s, p < 0.001), with arterial stiffness progressively worsening as the number of risk factors increased.
Cross-Sectional (n=81)
No
Does the clustering of metabolic syndrome risk factors increase arterial stiffness in non-diabetic and non-hypertensive patients?
In non-diabetic and non-hypertensive patients, the clustering of metabolic syndrome risk factors progressively increases arterial stiffness, with triglycerides acting as a significant independent predictor alongside age and systolic blood pressure.
Absolute Event Rate: 7.8% vs 7%
p-value: p=<0.001
BACKGROUND: Metabolic syndrome (MetS) is associated with structural and functional vascular abnormalities, which may lead to increased arterial stiffness, more frequent cardiovascular events and higher mortality. However, the role played by clustering of risk factors and the combining pattern of MetS risk factors and their association with the arterial stiffness have yet to be fully understood. Age, hypertension and diabetes mellitus seem to be strongly associated with increased pulse wave velocity (PWV). This study aimed at determining the clustering and combining pattern of MetS risk factors and their association with the arterial stiffness in non-diabetic and non-hypertensive patients. METHODS: ). Arterial stiffness was evaluated by PWV in the carotid-femoral segment. Patients were categorized and analyzed according MetS risk factors clustering (3, 4 and 5 factors) and its combinations. RESULTS: Patients with MetS had increased PWV when compared to Control (7.8 ± 1.1 vs. 7.0 ± 0.5 m/s, p < 0.001). In multivariate analysis, the variables that remained as predictors of PWV were age (β = 0.450, p < 0.001), systolic blood pressure (β = 0.211, p = 0.023) and triglycerides (β = 0.212, p = 0.037). The increased number of risk factors reflected in a progressive increase in PWV. When adjusted to systolic blood pressure, PWV was greater in the group with 5 risk factors when compared to the group with 3 risk factors and Control (8.5 ± 0.4 vs. 7.5 ± 0.2, p = 0.011 and 7.2 ± 0.3 m/s, p = 0.012). Similarly, the 4 risk factors group had higher PWV than the Control (7.9 ± 0.2 vs. 7.2 ± 0.3, p = 0.047). CONCLUSIONS: The number of risk factors seems to increase arterial stiffness. Notably, besides age and increased systolic blood pressure, alterations in the triglycerides worsened the stiffness of large vessels, emphasizing the importance in addressing this risk factor in MetS patients.
Lopes‐Vicente et al. (Wed,) conducted a cross-sectional in Metabolic syndrome (n=81). Metabolic syndrome (clustering of risk factors) vs. Control (without metabolic syndrome) was evaluated on Pulse wave velocity (PWV) in the carotid-femoral segment (p=<0.001). Patients with metabolic syndrome had significantly increased pulse wave velocity compared to controls (7.8 vs. 7.0 m/s, p < 0.001), with arterial stiffness progressively worsening as the number of risk factors increased.