Key result
Overexpression of dominant-negative CREB inhibited PGF2alpha-induced hypertrophy of vascular smooth muscle cells (hypertrophy index 8.43 vs 9.85 with PGF2alpha alone).
Why the study?
Does the CREB pathway mediate PGF2alpha-induced hypertrophy in vascular smooth muscle cells?
Population
Vascular smooth muscle cells (VSMCs)
Comparison
Prostaglandin F2alpha stimulation, with or… vs Control (unstimulated VSMCs)
Design
Preclinical
Authors
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Identifies CREB as mediator of PGF2α-induced VSMC hypertrophy in vitro; leaves open in vivo vascular remodeling effects.
Does the CREB pathway mediate PGF2alpha-induced hypertrophy in vascular smooth muscle cells?
Absolute Event Rate: 9.85% vs 8.13%
PGF2alpha induces vascular smooth muscle cell hypertrophy through EGFR transactivation and subsequent CREB pathway activation.
Fukuyama et al. (2005) studied Vascular smooth muscle cell hypertrophy. Prostaglandin F2alpha (PGF2alpha) and dominant-negative CREB (AdCREB M1) vs. Control was evaluated on Hypertrophy index (microg/10^4 cell). Overexpression of dominant-negative CREB inhibited PGF2alpha-induced hypertrophy of vascular smooth muscle cells (hypertrophy index 8.43 vs 9.85 with PGF2alpha alone).
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