Directed C–H alkynylation achieves broad functional group compatibility in quinazolin-4-one scaffolds, indicating versatility.
The directed C–H alkynylation of 2-(hetero)arylquinazolin-4-ones has been explored with the ethynylbenziodoxolone reagent TIPS-EBX employing an Ir(III) catalyst. Complementary conditions for either monoalkynylation or dialkynylation have been developed. Also demonstrated is the broad scope of this reaction and the compatibility of various functional groups such as −F, −Cl, −Br, −CF3, −OMe, −NO2, and alkyl, etc.
No takes yet. Share an insight, caveat, or question.
Rohokale et al. (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: