Key result
Antisaccade trials consistently activated a fronto-subcortical-parietal network to a greater extent than prosaccade trials, additionally recruiting the dorsolateral prefrontal cortex, anterior cingulate, and cerebellar tonsil.
Why the study?
Does the antisaccade task activate different neural regions compared to the prosaccade task in fMRI and PET studies?
Population
18 published voxel-wise fMRI and PET studies of the antisaccade task
Comparison
Antisaccade task vs Prosaccade task
Design
Meta-analysis
Authors
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Antisaccade fMRI can probe executive control networks in clinical assessments; confirms distributed recruitment beyond classic oculomotor regions across studies.
Meta-Analysis (n=315)
Does the antisaccade task activate different neural regions compared to the prosaccade task in fMRI and PET studies?
p-value: p=<0.05
The antisaccade task consistently activates a distributed fronto-subcortical-parietal network, including regions outside the classic oculomotor network, to a greater extent than prosaccades.
Jamadar et al. (2013) conducted a meta-analysis in Healthy (n=315). Antisaccade task vs. Prosaccade task or fixation was evaluated on Consistent brain activation regions (Activation Likelihood Estimation) (p=<0.05). Antisaccade trials consistently activated a fronto-subcortical-parietal network to a greater extent than prosaccade trials, additionally recruiting the dorsolateral prefrontal cortex, anterior cingulate, and cerebellar tonsil.
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