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December 6, 2018Molecular Therapy — Methods & Clinical DevelopmentOpen Access

A Self-Deleting AAV-CRISPR System for In Vivo Genome Editing

Ang Li Ciaran M. Lee Ayrea Hurley Kelsey E. Jarrett Marco De Giorgi Weiqi Lu Karol S. Balderrama Alexandria M. Doerfler Harshavardhan Deshmukh Anirban Ray Gang Bao William R. Lagor

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Abstract

. This self-deleting AAV-CRISPR system is an important proof of concept that will help enable translation of liver-directed genome editing in humans.

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Li et al. (2018) studied this question.

synapsesocial.com/papers/6a21cae04c1bee377cecadd1 https://doi.org/10.1016/j.omtm.2018.11.009

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